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The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with super-high potency corticosteroids such as clobetasol propionate (and, in the case of cream and ointment, with the use of occlusive dressings). These reactions are listed in an approximately decreasing order of occurrence: dryness, hypertrichosis (emollient and gel only), acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, irritation (cream, ointment, and gel only), striae, and miliaria.
In controlled clinical trials, the most frequent adverse reactions reported for clobetasol propionate cream were burning and stinging sensation in 1% of treated patients. Less frequent adverse reactions were itching, skin atrophy, and cracking and fissuring of the skin.
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